[last lines]
Sherlock Holmes : What is the meaning of it, Watson?
What is the object of this circle of misery and violence and fear?
It must have a purpose. Or our universe has no meaning and that is unthinkable.
But what purpose?
[pause]
Sherlock Holmes : That...
[pause]
Sherlock Holmes : is humanity's great problem to which reason, so far, has no answer.

-- Adventures of Sherlock Holmes, Jeremy Brett